Rejuran effect explained
Rejuran therapy uses a polynucleotide solution derived from salmon DNA to stimulate skin regeneration. The core component, DOT-C-PDRN, activates fibroblasts and supports collagen and elastin synthesis. Clinically, this translates into improved texture, smoother surfaces, and enhanced resilience over time.
Immediately after injections, mild redness or swelling may occur, but most reactions resolve quickly. The Rejuran effect unfolds gradually as cells respond to bioactive DNA fragments. Because benefits accumulate with time, sessions are typically spaced several weeks apart. Some clinics pair Rejuran with soothing components such as Centella derivatives to support calming post-treatment skin.
Korean clinical cases
In Korean dermatology, acne scar patients often show texture improvements after three sessions. Clinics in Seoul, particularly in districts like Gangnam, typically space injections 4 to 6 weeks apart. This pacing supports gradual collagen remodeling while avoiding tissue overload.
Post-inflammatory hyperpigmentation can improve when paired with proper sun protection. Patients may notice gradual tone evenness and smoother skin texture over months. Educating patients on realistic timelines helps set expectations for results.
DOT-C PDRN mechanism
DOT-C-PDRN delivers DNA fragments that resemble natural signaling in skin. DOT-C-PDRN engages fibroblasts and triggers collagen and elastin production. This promotes matrix remodeling and improves skin elasticity over time.
Delivery modalities matter, and hydrogel carriers help distribute bioactive components evenly. Korean clinics optimize injection depth and volume to balance efficacy and comfort. Understanding the mechanism helps clinicians tailor treatment plans for scars, aging skin, and irritation.
Safety considerations
Like any injectable therapy, safety depends on product quality and technique. Common transient reactions include redness, swelling, and minor tenderness at the site. Most adverse events resolve within days when aftercare is properly followed.
Appropriate intervals between sessions prevent overstimulation of the skin. Regulatory standards and professional training in Korea emphasize patient selection and informed consent. Collaboration with dermatologists ensures monitoring of outcomes and safety.